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CONTRACTED MANUFACTURE

受託製造

CHEMICALS

Customer case studies

Example 4:Customer D (foreign pharmaceutical manufacturer)

Foreign customer D manufacturing pharmaceutical products considered reducing the cost for API they were developing. Therefore, they focused on our synthetic method of 2-pyridine derivative as a manufacturing method of intermediate.
Cross-coupling reaction, Ullmann reaction or Suzuki-Miyaura coupling reaction are generally used for synthesizing 2-pyridine derivative. However, there exist some problems that these synthetic method require expensive metal catalyst or reagent, and the cost is high due to metal removal.

Product:Intermediate

・Expensive metal catalysts and regents are required to construct the skeleton of 2-pyridine.
・The process to remove metal is required.

Succeed in reducing 55% of the cost by introducing our original synthetic method for pyridine derivative.

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Example 3:Customer C (pharmaceutical manufacturer)

Although customer C manufacturing pharmaceutical products formerly consigned production of an API, it was not demanded due to the change of product lineup, so it was not manufactured for a long time. After that, they became to use the API for another product again and they were considering consigning production again.
We accepted the information from company C and then, examined the API and its crystallization process. As a result, we confirmed the following problems.

Product:API

Since each crystal has different solubility, bioavailability and stability depending on its shape, medicinal effect of pharmaceutical products may change. The precipitation and transition of stable crystal must be prevented because the object is metastable crystal* in this case.

Ensure the requisite quality by identifying the missing know-how of crystallization based on the accumulated knowledge.

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*Stable crystal has high melting point and low solubility under the same conditions (solvent, temperature etc.). Meanwhile, metastable crystal has lower melting point and higher solubility than that of stable crystal. In general, metastable form tends to transit to stable form and is unstable.

Example 2:Customer B (pharmaceutical manufacturer)

Customer B manufacturing pharmaceutical products considered consigning production of a main API through the development of a new products.
Through repeated meeting with company B, we performed crystallization examination based on the information from them. As a result, it was confirmed that the crystallization process of the compound had the following problem.

Product:API

Since the filterability of crystal is lower than the previous assumption, the filtrate cannot pass through for several hours. Therefore, the productivity is very low.

Succeed in achieving the scale-up in a shorter time than expected by solving the serious "low filterability".

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Example 1:Customer A (industrial materials manufacturer)

Customer A manufacturing industrial highly-functional films had a potential business issue of reducing the manufacturing cost and improving the profitability and price competitiveness. Accordingly, they considered outsourcing the production of organic compounds. Then, we had an inquiry from them.
To examine the crystallization process of the compound, we actually performed crystallization while changing solvent ratio, temperature, stirring condition and so on, and investigated the quality and filterability. As a result, we confirmed that the former process had the following problems, and share the matter with customer A.

Product:Film material

・The content of the obtained object from crystal is less than expected and there are much impurities (reaction by-products).
・Since it takes time to separate into solid and liquid after crystallization, the producibility is poor.

Succeed in reducing the manufacturing cost of 50 million yen per year by identifying the problem of crystallization process and improving it.

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